Max Planck Institute of Immunobiology and Epigenetics
The Max Planck Institute of Immunobiology and Epigenetics (German: ''Max-Planck-Institut für Immunbiologie und Epigenetik'') in Freiburg, Germany is an interdisciplinary research institute that conducts basic research in modern immunobiology, dev ...
California Institute of Technology
The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...
as Professor of Physics and the
Massachusetts Institute of Technology
The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the ...
as Professor of Physics and Biology. He has won several awards for his work, including in 2021 the
MacArthur Fellowship
The MacArthur Fellows Program, also known as the MacArthur Fellowship and commonly but unofficially known as the "Genius Grant", is a prize awarded annually by the MacArthur Foundation, John D. and Catherine T. MacArthur Foundation typically to ...
super-resolution imaging
Super-resolution imaging (SR) is a class of techniques that enhance (increase) the resolution of an imaging system. In optical SR the diffraction limit of systems is transcended, while in geometrical SR the resolution of digital imaging sensors i ...
Niamey
Niamey () is the capital and largest city of Niger. Niamey lies on the Niger River, primarily situated on the east bank. Niamey's population was counted as 1,026,848 as of the 2012 census. As of 2017, population projections show the capital di ...
,
Niger
)
, official_languages =
, languages_type = National languages He became interested in science through
Hollywood
Hollywood usually refers to:
* Hollywood, Los Angeles, a neighborhood in California
* Hollywood, a metonym for the cinema of the United States
Hollywood may also refer to:
Places United States
* Hollywood District (disambiguation)
* Hollywood, ...
films. In
Niamey
Niamey () is the capital and largest city of Niger. Niamey lies on the Niger River, primarily situated on the east bank. Niamey's population was counted as 1,026,848 as of the 2012 census. As of 2017, population projections show the capital di ...
there were few opportunities to practise science as his school did not have a
laboratory
A laboratory (; ; colloquially lab) is a facility that provides controlled conditions in which scientific or technological research, experiments, and measurement may be performed. Laboratory services are provided in a variety of settings: physicia ...
. He was keen to move to America to study, and completed high school two years early. He moved to the
United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territorie ...
North Carolina Central University
North Carolina Central University (NCCU or NC Central) is a public historically black university in Durham, North Carolina. Founded by James E. Shepard in affiliation with the Chautauqua movement in 1909, it was supported by private funds from b ...
and graduated in 2004. During his undergraduate degree he was encouraged by
Carl Wieman
Carl Edwin Wieman (born March 26, 1951) is an American physicist and educationist at Stanford University, and currently the A.D White Professor at Large at Cornell University. In 1995, while at the University of Colorado Boulder, he and Eric All ...
to apply for a fellowship, and spent a summer at
Princeton University
Princeton University is a private university, private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth, New Jersey, Elizabeth as the College of New Jersey, Princeton is the List of Colonial Colleges, fourth-oldest ins ...
working in
condensed matter physics
Condensed matter physics is the field of physics that deals with the macroscopic and microscopic physical properties of matter, especially the solid and liquid phases which arise from electromagnetic forces between atoms. More generally, the sub ...
. During this summer project he looked at jammed disordered packings, investigating how
M&M's
M&M's (stylized as m&m's) are multi-colored button-shaped chocolates, each of which has the letter "m" printed in lower case in white on one side, consisting of a candy shell surrounding a filling which varies depending upon the variety of M&M ...
magnetic resonance imaging
Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio wave ...
, but in the end used a much simpler approach - painting
M&M's
M&M's (stylized as m&m's) are multi-colored button-shaped chocolates, each of which has the letter "m" printed in lower case in white on one side, consisting of a candy shell surrounding a filling which varies depending upon the variety of M&M ...
and analysing how many times they knocked into each other. The result was published in
Science
Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe.
Science may be as old as the human species, and some of the earliest archeological evidence for ...
. He moved to Urbana for his graduate studies, and earned his PhD under the supervision of single molecule biophysicist
Taekjip Ha
Taekjip Ha (born February 20, 1968, Seoul, South Korea) is a South Korean-born American biophysicist who is currently a Bloomberg Distinguished Professor of Biophysics and Biomedical Engineering at Johns Hopkins University. He was previously the ...
at the
University of Illinois at Urbana–Champaign
The University of Illinois Urbana-Champaign (U of I, Illinois, University of Illinois, or UIUC) is a public land-grant research university in Illinois in the twin cities of Champaign and Urbana. It is the flagship institution of the Universit ...
in Paris. He worked as a Pierre Gilles de Gennes Fellow in the joint labs of a physicist, Maxime Dahan, and a biologist, Xavier Darzacq. He also held a long-term fellowship with the
European Molecular Biology Organization
The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 1,800 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...
photoactivated localization microscopy
Photo-activated localization microscopy (PALM or FPALM)
and stochastic optical reconstruction microscopy (STORM) are widefield (as opposed to point scanning techniques such as laser scanning confocal microscopy) fluorescence microscopy imaging meth ...
(tcPALM), allowing for time resolved measurements
in vitro
''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology an ...
PALM
Palm most commonly refers to:
* Palm of the hand, the central region of the front of the hand
* Palm plants, of family Arecaceae
**List of Arecaceae genera
* Several other plants known as "palm"
Palm or Palms may also refer to:
Music
* Palm (ba ...
to demonstrated that
RNA polymerase II
RNA polymerase II (RNAP II and Pol II) is a multiprotein complex that transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNAP enzymes found in the nucleus of eukaryoti ...
RNA polymerase
In molecular biology, RNA polymerase (abbreviated RNAP or RNApol), or more specifically DNA-directed/dependent RNA polymerase (DdRP), is an enzyme that synthesizes RNA from a DNA template.
Using the enzyme helicase, RNAP locally opens the ...
Howard Hughes Medical Institute
The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fil ...
. He worked in the
Janelia Research Campus
Janelia Research Campus is a scientific research campus of the Howard Hughes Medical Institute that opened in October 2006. The campus is located in Loudoun County, Virginia, near the town of Ashburn. It is known for its scientific research and m ...
Massachusetts Institute of Technology
The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the ...
in 2014. He uses
super-resolution microscopy
Super-resolution microscopy is a series of techniques in optical microscopy that allow such images to have resolutions higher than those imposed by the diffraction limit, which is due to the diffraction of light. Super-resolution imaging techni ...
to understand how genes are turned on and off. Gene activation involves that transcription of DNA information into molecules of
RNA
Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...
. This transcription involves the enzyme
RNA polymerase
In molecular biology, RNA polymerase (abbreviated RNAP or RNApol), or more specifically DNA-directed/dependent RNA polymerase (DdRP), is an enzyme that synthesizes RNA from a DNA template.
Using the enzyme helicase, RNAP locally opens the ...
PALM
Palm most commonly refers to:
* Palm of the hand, the central region of the front of the hand
* Palm plants, of family Arecaceae
**List of Arecaceae genera
* Several other plants known as "palm"
Palm or Palms may also refer to:
Music
* Palm (ba ...
to demonstrate that the lifetime of a
RNA polymerase
In molecular biology, RNA polymerase (abbreviated RNAP or RNApol), or more specifically DNA-directed/dependent RNA polymerase (DdRP), is an enzyme that synthesizes RNA from a DNA template.
Using the enzyme helicase, RNAP locally opens the ...
cluster impacts how many
RNA
Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...
messages are sent from a gene. He showed that clusters of almost 100
RNA polymerase
In molecular biology, RNA polymerase (abbreviated RNAP or RNApol), or more specifically DNA-directed/dependent RNA polymerase (DdRP), is an enzyme that synthesizes RNA from a DNA template.
Using the enzyme helicase, RNAP locally opens the ...
s form for around 10 seconds close to the sites of activating genes. He has studied molecules of proteins in mouse embryonic
stem cell
In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type o ...
RNA
Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...
.
On September 8, 2020, the
Vilcek Foundation
The Vilcek Foundation raises awareness of immigrant contributions to the United States, and fosters appreciation of the arts and sciences. The foundation's flagship programs include the Vilcek Foundation Prizes, which recognize and support immigra ...
Massachusetts Institute of Technology
The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the ...
California Institute of Technology
The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...
In 2021, he joined the Max Planck Institute of Immunobiology and Epigenetics as director.
Awards and honours
* 2021
MacArthur Fellowship
The MacArthur Fellows Program, also known as the MacArthur Fellowship and commonly but unofficially known as the "Genius Grant", is a prize awarded annually by the MacArthur Foundation, John D. and Catherine T. MacArthur Foundation typically to ...
* 2021 Vilcek Prize for Creative Promise in Biomedical Science
* 2018 Science News SN10: Scientists to Watch.
*2017 Biophysical Society
Horiba
is a Japanese manufacturer of precision instruments for measurement and analysis. They make instruments that measure and analyze automobile exhaust gas (80% share of the world market), and environmental, medical and scientific applications.
Ho ...
Young Fluorescence Investigator Award
* 2017 Pew Scholar in Biomedical Sciences
* 2014
National Institutes of Health
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...