ISAM-140 is a selective non- xanthinic adenosine A_2B

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

atagonist. Discovered in 2016, has a K''_i'' of 3.49 nM in A_2B

and >1000-fold selectivity with respect to the other three adenosine receptor subtypes. It has been shown to help immune system to attack

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...

cells in ''in vitro'' assays, by rescuing T and NK cell proliferation,

cytokine Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are peptides and cannot cross the lipid bilayer of cells to enter the cytoplasm. Cytokines have been shown to be involved in autocrin ...

release and TIL infiltration.

References

{{reflist 2-Furyl compounds Esters Nitrogen heterocycles Heterocyclic compounds with 3 rings