Insulin receptor substrate 4 is a
protein that in humans is encoded by the ''IRS4''
gene.
IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.
Interactions
IRS4 has been shown to
interact with
CRK
Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the ''CRK'' gene.
The CRK protein participates in the Reelin signaling cascade downstream of DAB1.
Function
Adapter molecule crk is a member of ...
and
NISCH
Nischarin is a protein that in humans is encoded by the ''NISCH'' gene.
Function
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the inner layer of the plasma membrane as well as early and recycling endosome ...
.
References
Further reading
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