Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...
that in humans is encoded by the ''IMPDH2''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo
guanine
Guanine () ( symbol G or Gua) is one of the four main nucleobases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine (uracil in RNA). In DNA, guanine is paired with cytosine. The guanine nucleoside is c ...
nucleotide
Nucleotides are organic molecules consisting of a nucleoside and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecule ...
biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. IMPDH2 catalyzes the NAD-dependent oxidation of
inosine-5'-monophosphate into
xanthine-5'-monophosphate, which is then converted into
guanosine-5'-monophosphate.
IMPDH2 has been identified as an intracellular target of the natural product sanglifehrin A
Clinical significance
This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
See also
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IMP dehydrogenase
IMP or imp may refer to:
* Imp, a fantasy creature
Arts and entertainment Fictional characters
* Imp (She-Ra), a character in ''She-Ra: Princess of Power''
* Imp a character in '' Artemis Fowl: The Lost Colony''
* Imp, a character in the '' Clan ...
References
Further reading
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EC 1.1.1
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