Interleukin 12 receptor, beta 2 subunit is a subunit of the
interleukin 12 receptor
Interleukin 12 receptor is a type I cytokine receptor, binding interleukin 12. It consists of beta 1 and beta 2 subunits.
References
External links
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Type I cytokine receptors
{{membrane-protein-stub ...
. IL12RB2 is its human
gene.
''IL12RB2''
orthologs have been identified in all
mammal
Mammals () are a group of vertebrate animals constituting the class Mammalia (), characterized by the presence of mammary glands which in females produce milk for feeding (nursing) their young, a neocortex (a region of the brain), fur or ...
s for which complete genome data are available.
The protein encoded by this gene is a
type I Type 1 or Type I or ''variant'', may refer to:
Health
*Diabetes mellitus type 1 (also known as "Type 1 Diabetes"), insulin-dependent diabetes
* Type I female genital mutilation
* Type 1 personality
*Type I hypersensitivity (or immediate hypersensit ...
transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The co-expression of this and
IL12Rβ1 proteins was shown to lead to the formation of high-affinity
IL12 binding sites and reconstitution of IL12 dependent signaling. While the IL12Rβ1 subunit is
constitutively expressed, the expression of the IL12RB2 gene is up-regulated by
interferon gamma. In
Th1 cells, IL-12 signaling through the IL12 receptor leads to the
phosphorylation
In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, wh ...
of
STAT4 and continued Th1 differentiation. The IL12Rβ2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1
effector molecules.
The up-regulation of this gene is found to be associated with a number of infectious diseases, such as
Crohn's disease
Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract. Symptoms often include abdominal pain, diarrhea (which may be bloody if inflammation is severe), fever, abdominal distension ...
and
leprosy, which is thought to contribute to the inflammatory response and host defense.
Interactions
Interleukin 12 receptor, beta 2 subunit has been shown to
interact with
Janus kinase 2.
RNA editing
The mRNA of this protein is subject to RNA editing.
References
Further reading
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