Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a
type I cytokine receptor. IL9R also denotes its human
gene
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The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of
interleukin 9
Interleukin 9, also known as IL-9, is a pleiotropic cytokine (cell signalling molecule) belonging to the group of interleukins. IL-9 is produced by variety of cells like mast cells, NKT cells, Th2, Th17, Treg, ILC2, and Th9 cells in different ...
(IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the
pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Interactions
Interleukin-9 receptor has been shown to
interact
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See also
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Cluster of differentiation
References
Further reading
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External links
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Type I cytokine receptors
Clusters of differentiation
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