Interleukin-1 receptor (IL-1R) is a
cytokine receptor
Cytokine receptors are receptors that bind to cytokines.
In recent years, the cytokine receptors have come to demand the attention of more investigators than cytokines themselves, partly because of their remarkable characteristics, and partly bec ...
which binds
interleukin 1
The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.
Discovery
Discovery of these cytokines began with studies on t ...
.
Two forms of the receptor exist. The
type I receptor is primarily responsible for transmitting the
inflammatory effects of interleukin-1 (IL-1) while
type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.
Also opposing the effects of IL-1 is the
IL-1 receptor antagonist (IL-1RA).
The IL-1 receptor accessory protein (
IL1RAP
Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the ''IL1RAP'' gene.
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at ...
) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.
References
External links
*
Immunoglobulin superfamily cytokine receptors
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