The interleukin-18 receptor (IL-18R) is an
interleukin receptor
Interleukin receptors are a family of cytokine receptors for interleukins. They belong to the immunoglobulin superfamily.
Types
There are two main families of Interleukin receptors, Type 1 and Type 2.
Type 1
Type 1 interleukin receptors includ ...
of the
immunoglobulin superfamily
The immunoglobulin superfamily (IgSF) is a large protein superfamily of cell surface and soluble proteins that are involved in the recognition, binding, or adhesion processes of cells. Molecules are categorized as members of this superfamily ba ...
.
Endometrial
The endometrium is the inner epithelial layer, along with its mucous membrane, of the mammalian uterus. It has a basal layer and a functional layer: the basal layer contains stem cells which regenerate the functional layer. The functional layer ...
IL-18 receptor mRNA and the ratio of
IL-18 binding protein
Interleukin-18-binding protein is a protein that in humans is encoded by the ''IL18BP'' gene.
The protein encoded by this gene is an inhibitor of the proinflammatory cytokine
Cytokines are a broad and loose category of small proteins (~5–25 ...
to interleukin 18 are significantly increased in
adenomyosis
Adenomyosis is a medical condition characterized by the growth of cells that proliferate on the inside of the uterus (endometrium) atypically located among the cells of the uterine wall (myometrium), as a result, thickening of the uterus occurs. A ...
patients in comparison to normal people, indicating a role in its pathogenesis.
References
External links
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Clusters of differentiation
Immunoglobulin superfamily cytokine receptors
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