IGEPAL CA-630 is a nonionic, non-denaturing

detergent A detergent is a surfactant or a mixture of surfactants with cleansing properties when in dilute solutions. There are a large variety of detergents, a common family being the alkylbenzene sulfonates, which are soap-like compounds that are more ...

. Its official

IUPAC The International Union of Pure and Applied Chemistry (IUPAC ) is an international federation of National Adhering Organizations working for the advancement of the chemical sciences, especially by developing nomenclature and terminology. It is ...

name is octylphenoxypolyethoxyethanol. IGEPAL is a registered trademark of Rhodia. IGEPAL CA-630 is sold by

Sigma-Aldrich Sigma-Aldrich (formally MilliporeSigma) is an American chemical, life science, and biotechnology company that is owned by the German chemical conglomerate Merck Group. Sigma-Aldrich was created in 1975 by the merger of Sigma Chemical Company a ...

and is claimed to be a "chemically indistinguishable" substitute for

Nonidet P-40 Nonidet P-40 is a nonionic, non-denaturing detergent. Its official IUPAC name is octylphenoxypolyethoxyethanol. Nonidet is a trademark of Shell Chemical Co. Nonidet P-40 is sometimes abbreviated as NP-40, but should not be confused with a differe ...

(a trademark of Shell Chemical Company) which is no longer manufactured. However, a 2017 publication reported that IGEPAL 630 was ten-fold more potent than Nonidet P-40 in a tubulin polymerisation assay. All IGEPAL CA surfactants are derived from octylphenol. This serves as the hydrophobic part. Different amounts of

ethylene oxide Ethylene oxide is an organic compound with the chemical formula, formula . It is a cyclic ether and the simplest epoxide: a three-membered Ring (chemistry), ring consisting of one oxygen atom and two carbon atoms. Ethylene oxide is a colorless a ...

are combined with this part to get a balance of hydrophobic/hydrophilic substances (measured by HLB). This balance has an important impact on wetting detergency, foam, solubility, emulsification. IGEPAL CA-630 has HLB of 13.4, similar to that of

Triton X-100 Triton X-100 (''n'') is a nonionic surfactant that has a hydrophilic polyethylene oxide chain (on average it has 9.5 ethylene oxide units) and an aromatic hydrocarbon lipophilic or hydrophobic group. The hydrocarbon group is a 4-( 1,1,3,3-tetramet ...

(13.4) and thus belongs to the detergent range (HLB 13-15); this is significantly less than 17.8 of tergitol

NP-40 NP-40 (also known as Tergitol-type NP-40 and nonyl phenoxypolyethoxylethanol) is a commercially available detergent with CAS Registry Number 9016-45-9. NP-40 is an ethoxylated nonylphenol for non-ionic surfactants and can act as emulsifier and d ...

or 16.7 of

Polysorbate 20 Polysorbate 20 (common commercial brand names include Kolliphor PS 20, Scattics, Alkest TW 20, Tween 20, and Kotilen-20) is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan monolaurate. Its stability and relative n ...

(also known as Tween 20), which both belong in the solubilizer range (15-18) of HLB. Ca-630 is completely miscible with water.

Human Toxicity

CA-630 is not a primary skin irritant nor sensitizer. However, it is a severe eye irritant.http://www.mpbio.com/detailed_info.php?family_key=02198596

References

{{Reflist Non-ionic surfactants

Human Toxicity

See also

References