I-SMAD or Inhibitor SMAD is a subclass of
SMADs that are involved in the modulation of
transforming growth factor beta
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other sign ...
ligands
In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex. The bonding with the metal generally involves formal donation of one or more of the ligand's electro ...
. This class includes
SMAD6
SMAD family member 6, also known as SMAD6, is a protein that in humans is encoded by the ''SMAD6'' gene.
SMAD6 is a protein that, as its name describes, is a homolog of the Drosophila gene " mothers against decapentaplegic". It belongs to the SM ...
and
SMAD7
Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the ''SMAD7'' gene.
SMAD7 is a protein that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to ...
. They compete with
SMAD4
SMAD4, also called SMAD family member 4, Mothers against decapentaplegic homolog 4, or DPC4 (Deleted in Pancreatic Cancer-4) is a highly conserved protein present in all metazoans. It belongs to the SMAD family of transcription factor proteins, ...
and consequently regulate the transcription of its gene products.
See also
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SMAD (protein)
Smads (or SMADs) comprise a family of structurally similar proteins that are the main signal transducers for receptors of the transforming growth factor beta (TGF-B) superfamily, which are critically important for regulating cell development and gr ...
*
R-SMAD
External links
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{{molecular-cell-biology-stub
SMAD (protein)
Transcription factors