Interstate 375 may refer to:
*
Interstate 375 (Florida)
Interstate 375 (I-375) in St. Petersburg, Florida, also known as North Bay Drive, is a spur route from I-275 into downtown. It is also designated as the unsigned State Road 592 (SR 592). There is a sibling segment of freeway nea ...
, a spur in St. Petersburg, Florida
*
Interstate 375 (Michigan)
Interstate 375 (I-375) is a north–south auxiliary Interstate Highway in the city of Detroit, Michigan, United States. It is the southernmost leg of the Walter P. Chrysler Freeway and a spur of I-75 into Downtown Detroit, ending at the uns ...
, a spur in Detroit, Michigan
{{road disambiguation
3