Sir Henry Hallett Dale
(9 June 1875 – 23 July 1968) was an
English
English usually refers to:
* English language
* English people
English may also refer to:
Peoples, culture, and language
* ''English'', an adjective for something of, from, or related to England
** English national ...
pharmacologist
Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemic ...
and
physiologist
Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemica ...
.
For his study of
acetylcholine
Acetylcholine (ACh) is an organic chemical that functions in the brain and body of many types of animals (including humans) as a neurotransmitter. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Par ...
as agent in the
chemical transmission of nerve pulses (
neurotransmission
Neurotransmission (Latin: ''transmissio'' "passage, crossing" from ''transmittere'' "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), ...
) he shared the 1936
Nobel Prize in Physiology or Medicine
The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accordi ...
with
Otto Loewi
Otto Loewi (; 3 June 1873 – 25 December 1961) was a German-born pharmacologist and psychobiologist who discovered the role of acetylcholine as an endogenous neurotransmitter. For his discovery he was awarded the Nobel Prize in Physiology or M ...
.
Early life and education
Henry Hallett Dale was born in
Islington
Islington () is a district in the north of Greater London, England, and part of the London Borough of Islington. It is a mainly residential district of Inner London, extending from Islington's High Street to Highbury Fields, encompassing the ...
,
London
London is the capital and List of urban areas in the United Kingdom, largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary dow ...
, to Charles James Dale, a pottery manufacturer from
Staffordshire
Staffordshire (; postal abbreviation Staffs.) is a landlocked county in the West Midlands region of England. It borders Cheshire to the northwest, Derbyshire and Leicestershire to the east, Warwickshire to the southeast, the West Midlands C ...
, and his wife, Frances Anne Hallett, daughter of a furniture manufacturer, from South Devon.
[Feldberg W, rev. Tansey EM (2004–2011)]
Dale, Sir Henry Hallett (1875–1968)
''Oxford Dictionary of National Biography'', Oxford University Press, 2004; online edn, Jan 2011. Retrieved 2011-07-08. Henry was the third of seven children, one of whom (his younger brother,
Benjamin Dale
Benjamin James Dale (17 July 188530 July 1943) was an English composer and academic who had a long association with the Royal Academy of Music. Dale showed compositional talent from an early age and went on to write a small but notable corpus of ...
) became an accomplished composer and warden of the
Royal Academy of Music
The Royal Academy of Music (RAM) in London, England, is the oldest conservatoire in the UK, founded in 1822 by John Fane and Nicolas-Charles Bochsa. It received its royal charter in 1830 from King George IV with the support of the first Duke ...
. Henry was educated at the local
Tollington Park College and then
The Leys School
The Leys School is a co-educational independent school in Cambridge, England. It is a day and boarding school for about 574 pupils between the ages of eleven and eighteen, and a member of the Headmasters' and Headmistresses' Conference.
Histo ...
Cambridge (one of the school's houses is named after him) and in 1894 entered
Trinity College, Cambridge
Trinity College is a constituent college of the University of Cambridge. Founded in 1546 by King Henry VIII, Trinity is one of the largest Cambridge colleges, with the largest financial endowment of any college at either Cambridge or Oxford. ...
, working under the physiologist John Langley. For a few months in 1903 he also studied under
Paul Ehrlich
Paul Ehrlich (; 14 March 1854 – 20 August 1915) was a Nobel Prize-winning German physician and scientist who worked in the fields of hematology, immunology, and antimicrobial chemotherapy. Among his foremost achievements were finding a cure ...
in
Frankfurt
Frankfurt, officially Frankfurt am Main (; Hessian: , " Frank ford on the Main"), is the most populous city in the German state of Hesse. Its 791,000 inhabitants as of 2022 make it the fifth-most populous city in Germany. Located on it ...
, Germany. Also in 1903, Dale assisted
Ernest Starling
Ernest Henry Starling (17 April 1866 – 2 May 1927) was a British physiologist who contributed many fundamental ideas to this subject. These ideas were important parts of the British contribution to physiology, which at that time led the world ...
and
William Bayliss
Sir William Maddock Bayliss (2 May 1860 – 27 August 1924) was an English physiologist.
Life
He was born in Wednesbury, Staffordshire but shortly thereafter his father, a successful merchant of ornamental ironwork, moved his family to a ...
in the
vivisection
Vivisection () is surgery conducted for experimental purposes on a living organism, typically animals with a central nervous system, to view living internal structure. The word is, more broadly, used as a pejorative catch-all term for experiment ...
of a dog, by removing the dog's pancreas and then killing the dog with a knife, which ultimately led to the events of the
Brown Dog affair
The Brown Dog affair was a political controversy about vivisection that raged in Britain from 1903 until 1910. It involved the infiltration of University of London medical lectures by Swedish feminists, battles between medical students and th ...
. Dale received his
Doctor of Medicine
Doctor of Medicine (abbreviated M.D., from the Latin ''Medicinae Doctor'') is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the M.D. denotes a professional degree. ...
degree from Cambridge in 1909.
[
]
Career and research
While working at the University College London
, mottoeng = Let all come who by merit deserve the most reward
, established =
, type = Public research university
, endowment = £143 million (2020)
, budget = ...
, he met and became friends with Otto Loewi
Otto Loewi (; 3 June 1873 – 25 December 1961) was a German-born pharmacologist and psychobiologist who discovered the role of acetylcholine as an endogenous neurotransmitter. For his discovery he was awarded the Nobel Prize in Physiology or M ...
. Dale became the director of the Department of Biochemistry
Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...
and Pharmacology
Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...
at the National Institute for Medical Research
The National Institute for Medical Research (commonly abbreviated to NIMR), was a medical research institute based in Mill Hill, on the outskirts of north London, England. It was funded by the Medical Research Council (MRC);
In 2016, the NIMR b ...
in London in 1914. He became a Fullerian Professor of Chemistry at the Royal Institution
The Royal Institution of Great Britain (often the Royal Institution, Ri or RI) is an organisation for scientific education and research, based in the City of Westminster. It was founded in 1799 by the leading British scientists of the age, inc ...
in 1942. During World War II
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the World War II by country, vast majority of the world's countries—including all of the great power ...
he served on the scientific advisory panel to the Cabinet.
Although Dale and his colleagues first identified acetylcholine in 1914 as a possible neurotransmitter
A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse. The cell receiving the signal, any main body part or target cell, may be another neuron, but could also be a gland or muscle cell.
Neu ...
, Loewi showed its importance in the nervous system
In biology, the nervous system is the highly complex part of an animal that coordinates its actions and sensory information by transmitting signals to and from different parts of its body. The nervous system detects environmental changes ...
. The two men shared the 1936 Nobel Prize for Medicine.
During the 1940s Dale was embroiled in the scientific debate over the nature of signaling at the synapse
In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target effector cell.
Synapses are essential to the transmission of nervous impulses from ...
. Dale and others believed that signaling at the synapse was chemical, while John Carew Eccles and others believed that the synapse was electrical. It was later found that most synaptic signalling is chemical, but there are some synapses that are electrical.
Dale also originated the scheme used to differentiate neuron
A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa ...
s according to the neurotransmitters they release. Thus, neurons releasing noradrenaline
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as both a hormone and neurotransmitter. The name "noradrenaline" (from Latin '' ad'', ...
(known in the United States as norepinephrine
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as both a hormone and neurotransmitter. The name "noradrenaline" (from Latin '' ad ...
) are called noradrenergic, neurons releasing GABA are GABAergic
In molecular biology and physiology, something is GABAergic or GABAnergic if it pertains to or affects the neurotransmitter GABA. For example, a synapse is GABAergic if it uses GABA as its neurotransmitter, and a GABAergic neuron produces GABA. A ...
, and so on. This is called ''Dale's principle
In neuroscience, Dale's principle (or Dale's law) is a rule attributed to the English neuroscientist Henry Hallett Dale. The principle basically states that a neuron performs the same chemical action at all of its synaptic connections to other c ...
'' (sometimes erroneously referred to as ''Dale's Law''), one interpretation of which holds that each neuron releases only one type of neurotransmitter. This particular interpretation of Dale's principle has been shown to be false, as many neurons release neuropeptides
Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the ...
and amino acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha ...
s in addition to classical neurotransmitters such as acetylcholine or biogenic amines (see cotransmission
Neurotransmission (Latin: ''transmissio'' "passage, crossing" from ''transmittere'' "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), ...
) (Bear, et al. 2001). This finding, that numerous neurotransmitters can be released by the same neuron, is referred to as the "coexistence principle." This phenomenon was most popularized by the Swedish neuroanatomist and neuropharmacologist Tomas Hökfelt
Tomas Hökfelt (born 29 June 1940) is a Swedish physician and former professor in histology at the Karolinska Institutet from 1979 until 2006, when he got his emeritate. He was linked to the Department of Neuroscience and is specialized in cell bio ...
, who is considered to be the "Father of the Coexistence Principle."
Between 1938 and 1960 Dale served as chairman
The chairperson, also chairman, chairwoman or chair, is the presiding officer of an organized group such as a board, committee, or deliberative assembly. The person holding the office, who is typically elected or appointed by members of the group ...
of the Wellcome Trust
The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glaxo ...
.
Awards and honours
Dale was elected a Fellow of the Royal Society (FRS) in 1914. In 1926, he was awarded the Cameron Prize for Therapeutics of the University of Edinburgh
The Cameron Prize for Therapeutics of the University of Edinburgh is awarded by the College of Medicine and Veterinary Medicine to a person who has made any highly important and valuable addition to Practical Therapeutics in the previous five ye ...
. He was knight
A knight is a person granted an honorary title of knighthood by a head of state (including the Pope) or representative for service to the monarch, the Christian denomination, church or the country, especially in a military capacity. Knighthood ...
ed in 1932, receiving the Knight Grand Cross of the Order of the British Empire
The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations,
and public service outside the civil service. It was established ...
in 1943 and the Order of Merit
The Order of Merit (french: link=no, Ordre du Mérite) is an order of merit for the Commonwealth realms, recognising distinguished service in the armed forces, science, art, literature, or for the promotion of culture. Established in 1902 by ...
in 1944. He served as president
President most commonly refers to:
*President (corporate title)
* President (education), a leader of a college or university
* President (government title)
President may also refer to:
Automobiles
* Nissan President, a 1966–2010 Japanese ...
of the Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
from 1940 to 1945 and president of the Royal Society of Medicine
The Royal Society of Medicine (RSM) is a medical society in the United Kingdom, headquartered in London.
History
The Society was established in 1805 as Medical and Chirurgical Society of London, meeting in two rooms in barristers’ chambers ...
from 1948 to 1950. The Sir Henry Dale Fellow
A fellow is a concept whose exact meaning depends on context.
In learned or professional societies, it refers to a privileged member who is specially elected in recognition of their work and achievements.
Within the context of higher education ...
ships of the Wellcome Trust
The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glaxo ...
are named in his honour and the Society for Endocrinology
The Society for Endocrinology is an international membership organisation and registered charity representing scientists, clinicians and nurses who work with hormones. The Society was established in 1946, and currently has approximately 2,500 mem ...
awards the Dale Medal annually in his honour.
Personal life
In 1904, Dale had married his first cousin Elen Harriet Hallett and had a son and two daughters. One of their daughters, Alison Sarah Dale, married Alexander R. Todd, who too won the Nobel Prize and served as President of the Royal Society
The president of the Royal Society (PRS) is the elected Head of the Royal Society of London who presides over meetings of the society's council.
After informal meetings at Gresham College, the Royal Society was officially founded on 28 November ...
from 1940 to 1945. The Dales lived at Mount Vernon House from 1919 to 1942. Dales's residency at the house is marked by a Greater London Council
The Greater London Council (GLC) was the top-tier local government administrative body for Greater London from 1965 to 1986. It replaced the earlier London County Council (LCC) which had covered a much smaller area. The GLC was dissolved in 198 ...
blue plaque erected in 1981 on the garden wall of the house.
Henry Hallett Dale as child.jpg, Dale as a child
Henry Hallett Dale 1904.jpg, Dale in 1904
Henry Hallett Dale 1918.jpg, Dale in 1918
Henry Dale and wife.jpg, Dale with wife
Son of Henry Hallett Dale.jpg, Son of Henry Hallett Dale
DaleNobel20040420.jpg, The Nobel Prize diploma of Dale, displayed in the Royal Society, London.
Dale-Schuster pump.jpg, Dale-Schuster blood pump
References
External links
* including the Nobel Lecture, 12 December 1936 ''Some Recent Extensions of the Chemical Transmission of the Effects of Nerve Impulses''
{{DEFAULTSORT:Dale, Henry Hallett
1875 births
1968 deaths
People educated at The Leys School
Alumni of Trinity College, Cambridge
English neuroscientists
English pharmacologists
Knights Grand Cross of the Order of the British Empire
Nobel laureates in Physiology or Medicine
Fellows of the Royal Society
Foreign associates of the National Academy of Sciences
Presidents of the Royal Society
Presidents of the Royal Society of Medicine
Recipients of the Pour le Mérite (civil class)
Members of the Order of Merit
Royal Medal winners
Recipients of the Copley Medal
Knights Bachelor
English Nobel laureates
National Institute for Medical Research faculty
Academics of University College London