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Hydroxysteroid dehydrogenases (HSDs) are a group of
Hydroxysteroid dehydrogenases (HSDs) are a group of alcohol oxidoreductase
Alcohol oxidoreductases are oxidoreductase enzymes that act upon an alcohol functional group
In organic chemistry, a functional group is a substituent or moiety in a molecule that causes the molecule's characteristic chemical reactions. The sa ...
s that catalyze the dehydrogenation
In chemistry, dehydrogenation is a chemical reaction that involves the removal of hydrogen, usually from an organic molecule. It is the reverse of hydrogenation. Dehydrogenation is important, both as a useful reaction and a serious problem. At ...
of hydroxysteroid
A hydroxysteroid is a molecule derived from a steroid with a hydrogen replaced with a hydroxy group. When the hydroxy group is specifically at the C3 position, hydroxysteroids are referred to as sterols, with an example being cholesterol.
See a ...
s. These enzymes also catalyze the reverse reaction, acting as ketosteroid reductases (KSRs).
There are four types, classified by the number of the position acted upon:
See also
*Steroidogenic enzyme __NOTOC__
Steroidogenic enzymes are enzymes that are involved in steroidogenesis and steroid biosynthesis. They are responsible for the biosynthesis of the steroid hormones, including sex steroids (androgens, estrogens, and progestogens) and cortic ...
* Steroid hydroxylase
A steroid hydroxylase is a class of hydroxylase enzymes involved in the biosynthesis of steroids.
See also
* Steroidogenic enzyme
Additional images
File:Steroidogenesis.svg, Steroidogenesis
Image:Steroid numbering.svg, Steroid nomenclature †...
External links
* {{Portal bar, Biology, border=no EC 1.1.1