The

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...

hyaluronate lyase () catalyzes the

chemical reaction A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...

:Cleaves hyaluronate chains at a β-D-GalNAc-(1→4)-β-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-β-D-gluc-4-enuronosyl)-''N''-acetyl-D-glucosamine This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on polysaccharides. The

systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ...

of this enzyme class is hyaluronate lyase. Other names in common use include hyaluronidase (''ambiguous''), (hyalurononglucosaminidase) (''ambiguous''), (hyaluronoglucuronidase)], glucuronoglycosaminoglycan lyase, spreading factor, and mucinase (''ambiguous'').

Structural studies

As of late 2007, 27 tertiary structure, structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , , , , , , , , , , , , , , and .

References

* * * EC 4.2.2 Enzymes of known structure {{4.2-enzyme-stub