Human umbilical artery endothelial cells (HUAECs) are cells derived from the
endothelium
The endothelium is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vessel ...
of
arteries
An artery (plural arteries) () is a blood vessel in humans and most animals that takes blood away from the heart to one or more parts of the body (tissues, lungs, brain etc.). Most arteries carry oxygenated blood; the two exceptions are the pu ...
from the
umbilical cord
In placental mammals, the umbilical cord (also called the navel string, birth cord or ''funiculus umbilicalis'') is a conduit between the developing embryo or fetus and the placenta. During prenatal development, the umbilical cord is physiologic ...
. They are used as a laboratory model system for the study of the function and pathology of endothelial cells (e.g.,
atherosclerosis
Atherosclerosis is a pattern of the disease arteriosclerosis in which the wall of the artery develops abnormalities, called lesions. These lesions may lead to narrowing due to the buildup of atheroma, atheromatous plaque. At onset there are usu ...
). HUAECs have “
cobblestone
Cobblestone is a natural building material based on cobble-sized stones, and is used for pavement roads, streets, and buildings.
Setts, also called Belgian blocks, are often casually referred to as "cobbles", although a sett is distinct fro ...
” morphology.
References
External links
Human Umbilical Artery Endothelial Cells(HUVEC) Catalog #8010at ScienCell Research Laboratories, inc.
Cell culture
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