The Human Parechovirus 1 cis regulatory element is an
RNA element which is located in the 5'-terminal 112
nucleotide
Nucleotides are organic molecules consisting of a nucleoside and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules wi ...
s of the genome of human parechovirus 1 (HPeV1). The element consists of two
stem-loop
Stem-loop intramolecular base pairing is a pattern that can occur in single-stranded RNA. The structure is also known as a hairpin or hairpin loop. It occurs when two regions of the same strand, usually complementary in nucleotide sequence when ...
structures (SL-A and SL-B) together with a
pseudoknot
__NOTOC__
A pseudoknot is a nucleic acid secondary structure containing at least two stem-loop structures in which half of one stem is intercalated between the two halves of another stem. The pseudoknot was first recognized in the turnip yellow ...
. Disruption of any of these elements impairs both viral replication and growth.
See also
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Human rhinovirus internal cis-acting regulatory element (CRE)
Human rhinovirus internal cis-acting regulatory element (CRE) is
a CRE from the human rhinoviruses. The CRE is located within the genome segment encoding the capsid
A capsid is the protein shell of a virus, enclosing its genetic material. I ...
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Rotavirus cis-acting replication element (CRE)
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Parechovirus
''Parechovirus'' is a genus of viruses in the family ''Picornaviridae''. Humans, ferrets, and various rodents serve as natural hosts. The genus currently consists of six accepted species. Human parechoviruses may cause gastrointestinal or respira ...
References
External links
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Cis-regulatory RNA elements
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