Hovione is a Portuguese multinational company that produces

active pharmaceutical ingredient An active ingredient is any ingredient that provides biologically active or other direct effect in the diagnosis, cure, mitigation, treatment, or prevention of disease or to affect the structure or any function of the body of humans or animals. The ...

s (APIs) and conducts drug product intermediates development and compliant manufacture. It is a Contract Development and Manufacturing Company (CDMO) dedicated to helping pharmaceutical customers bring new and off-patent drugs to market. With sites in the

United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territori ...

Portugal Portugal, officially the Portuguese Republic ( pt, República Portuguesa, links=yes ), is a country whose mainland is located on the Iberian Peninsula of Southwestern Europe, and whose territory also includes the Atlantic archipelagos of ...

Ireland Ireland ( ; ga, Éire ; Ulster Scots dialect, Ulster-Scots: ) is an island in the Atlantic Ocean, North Atlantic Ocean, in Northwestern Europe, north-western Europe. It is separated from Great Britain to its east by the North Channel (Grea ...

and China, it provides products and services to the

pharmaceutical industry The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications to be administered to patients (or self-administered), with the aim to cure them, vaccinate them, or alleviate symptoms. ...

, including separate and integrated API, pre-formulated compounds, particle engineering, formulation development and

manufacturing Manufacturing is the creation or production of goods with the help of equipment, labor, machines, tools, and chemical or biological processing or formulation. It is the essence of secondary sector of the economy. The term may refer to ...

. It also supports highly potent compounds and proprietary product development and licensing for drug products. It is also present in the inhalation area.

History

Hovione was established in Portugal in 1959 by Ivan Villax with his wife, Diane Villax, and two other Hungarian refugees: Nicholas de Horthy and Andrew Onody, the first two letters of the three founders’ names: HO, VI and ON were used to create the name Hovione. Hovione continues to be a privately held company with 5 plants - in

(1969),

Macao Macau or Macao (; ; ; ), officially the Macao Special Administrative Region of the People's Republic of China (MSAR), is a city and special administrative region of China in the western Pearl River Delta by the South China Sea. With a po ...

(1986),

New Jersey New Jersey is a state in the Mid-Atlantic and Northeastern regions of the United States. It is bordered on the north and east by the state of New York; on the east, southeast, and south by the Atlantic Ocean; on the west by the Delaware ...

(2001) expanded in 2016, Taizhou in mainland China (2008) and

Cork Cork or CORK may refer to: Materials * Cork (material), an impermeable buoyant plant product ** Cork (plug), a cylindrical or conical object used to seal a container ***Wine cork Places Ireland * Cork (city) ** Metropolitan Cork, also known as G ...

, Ireland (2009) - have a total reactor capacity of 1300 m³ and 1100 people worldwide. Since Hovione started operations in 1959, the company has patented more than 100 innovative chemical processes and produced industrially over 45 different APIs. All Hovione sites have been successfully inspected either by FDA, European Medicines Agency or the PMDA Japanese agency. Hovione is a major source of

semi-synthetic Semisynthesis, or partial chemical synthesis, is a type of chemical synthesis that uses chemical compounds isolated from natural sources (such as microbial cell cultures or plant material) as the starting materials to produce novel compounds with ...

tetracycline Tetracycline, sold under various brand names, is an oral antibiotic in the tetracyclines family of medications, used to treat a number of infections, including acne, cholera, brucellosis, plague, malaria, and syphilis. Common side effects in ...

s and corticosteroids, and is the largest independent supplier of

contrast agents A contrast agent (or contrast medium) is a substance used to increase the contrast of structures or fluids within the body in medical imaging. Contrast agents absorb or alter external electromagnetism or ultrasound, which is different from radiop ...

– these three families of compounds make up most of its generic product portfolio. The other half of the business focuses on exclusive projects: * Development and manufacture of innovator APIs * Particle Engineering: manipulations of physical properties of APIs, polymeric encapsulation * Development of formulations for pulmonary delivery

Research and development

Hovione has two R&D centers with a team of over 270

scientists A scientist is a person who conducts scientific research to advance knowledge in an area of the natural sciences. In classical antiquity, there was no real ancient analog of a modern scientist. Instead, philosophers engaged in the philosophica ...

, one in

- Loures and another one in its facilities in

. Hovione has international partnerships, including with

Cambridge Cambridge ( ) is a College town, university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cam ...

and

MIT The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the m ...

. In 2016, 7 PhDs were simultaneously running and it has launched a scientific program named "9oW", which challenges scientific and academic communities to help overcoming technological challenges. Also, Hovione is already the largest private employer of doctorates in Portugal (57 doctorates in Loures).

Strategy

Hovione was always present in the pharmaceutical industry offering products and services related to the development and manufacture of either a

new chemical entity A new chemical entity (NCE) is, according to the U.S. Food and Drug Administration, a novel, small, chemical molecule drug that is undergoing clinical trials or has received a first approval (not a new use) by the FDA in any other application submi ...

(NCE) for an exclusive contract

partner or an existing API for an off-patent product. Today, it is an integrated solution provider, from process chemistry to particle engineering to formulation, from very small scale to full commercial capacity and from

preclinical In drug development, preclinical development, also termed preclinical studies or nonclinical studies, is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug ...

market Market is a term used to describe concepts such as: *Market (economics), system in which parties engage in transactions according to supply and demand *Market economy *Marketplace, a physical marketplace or public market Geography *Märket, an ...

. In the area of

technology Technology is the application of knowledge to reach practical goals in a specifiable and Reproducibility, reproducible way. The word ''technology'' may also mean the product of such an endeavor. The use of technology is widely prevalent in me ...

, it has capabilities in

spray drying Spray drying is a method of changing a dry powder from a liquid or slurry by rapidly drying with a hot gas. This is the preferred method of drying of many thermally-sensitive materials such as foods and pharmaceuticals, or materials which may requ ...

(also for potent drugs), spray congealing, fluidized spray drying, aseptic spray drying, jet milling, controlled crystallization, microfluidization, continuous manufacturing, continuous tableting. And methodologies Quality by Design,

process analytical technology Process analytical technology (PAT) has been defined by the United States Food and Drug Administration (FDA) as a mechanism to design, analyze, and control pharmaceutical manufacturing processes through the measurement of critical process paramete ...

(PAT), britest,

lean Lean, leaning or LEAN may refer to: Business practices * Lean thinking, a business methodology adopted in various fields ** Lean construction, an adaption of lean manufacturing principles to the design and construction process ** Lean governm ...

, scale-up science, modeling. Hovione invested about $100 million in 2017 and plans to spend as much again this year and next. The plan over the next three years is to continue investing, especially in Portugal, where the firm will add 165 m³ of chemical synthesis capacity, a spray-dryer building, and a 1,200-m² analytical lab.

References

External links

Hovione Website
{{Authority control Pharmaceutical companies of Portugal Pharmaceutical companies established in 1959 1959 establishments in Portugal Portuguese brands