The Holin Superfamily I (aka the
CDD phage holin1 superfamily) is a
superfamily
SUPERFAMILY is a database and search platform of structural and functional annotation for all proteins and genomes. It classifies amino acid sequences into known structural domains, especially into SCOP superfamilies. Domains are functional, str ...
of integral
membrane transport proteins. It is one of the seven different
holin superfamilies in total. In general, these proteins are thought to play a role in regulated cell death, although functionality varies between families and individual members.
Its main constituent is the
Phi11 Holin (φ11 Holin) Family. This family is made up of over 270 putative pore-forming proteins, all from ''
Bacillota''. On average, proteins belonging to the holin I superfamily are about 100 amino acyl residues (aas) in length, although a large size variation exists among proteins of this superfamily. There does not seem to be deviation from the standard two transmembrane segments that these proteins possess.
See also
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Holins
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Lysin
Lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages in order to cleave the host's cell wall during the final stage of the lytic cycle. Lysins are highly evolved enzymes that are able to target ...
*
Transporter Classification Database
References
Holins
Protein superfamilies
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