The holin LLH family (TC# 1.E.26) is a group of transporters belonging to the
Holin superfamily VI The Holin superfamily VI is a superfamily of integral membrane transport proteins. It is one of the seven different holin superfamilies in total. In general, these proteins are thought to play a role in regulated cell death, although functionality ...
. The Holin LLH family is found in
Bacillota and phage of Bacillota as well as other bacteria. Members are fairly large, between 100 and 160 amino acyl residues in length, and have an
N-terminal
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the ami ...
transmembrane segment (TMS). Some proteins, such as putative holin of ''Fusobacterium varium''
TC# 1.E.26.7.2, may exhibit 2 TMSs. A representative list of proteins belonging to the Holin LLH family can be found in the Transporter Classification Database.
Transporter Classification Database
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See also
* Holin/Holin Superfamilies
* Lysin
Lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages in order to cleave the host's cell wall during the final stage of the lytic cycle. Lysins are highly evolved enzymes that are able to target ...
* Transporter Classification Database
Further reading
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References
{{CCBYSASource, sourcepath=http://www.tcdb.org/search/result.php?tc=1.E.26, sourcearticle=1.E.26 The Holin LLH (Holin LLH) Family, revision=699838558
Holins
Protein families