The histone 3′ UTR stem-loop is an
RNA element involved in nucleocytoplasmic transport of the
histone mRNAs, and in the regulation of stability and of translation efficiency in the
cytoplasm
In cell biology, the cytoplasm is all of the material within a eukaryotic cell, enclosed by the cell membrane, except for the cell nucleus. The material inside the nucleus and contained within the nuclear membrane is termed the nucleoplasm. ...
. The
mRNAs of
metazoan histone genes lack
polyadenylation and a
poly-A tail, instead 3′ end processing occurs at a site between this highly conserved stem-loop and a
purine rich region around 20
nucleotides downstream (the histone downstream element, or HDE). The
stem-loop
Stem-loop intramolecular base pairing is a pattern that can occur in single-stranded RNA. The structure is also known as a hairpin or hairpin loop. It occurs when two regions of the same strand, usually complementary in nucleotide sequence wh ...
is bound by a 31 kDa stem-loop binding protein (
SLBP - also termed the histone hairpin binding protein, or HBP). Together with
U7 snRNA binding of the HDE, SLBP binding nucleates the formation of the processing complex.
References
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External links
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Transterm page for Histone 3′ stem loopUTRSite page for Histone 3′UTR stem-loop structure (HSL3)
Cis-regulatory RNA elements
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