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Route 380 or Highway 380 may refer to:
Interstate 380
* 
U.S. Route 380
* 
Arizona State Route 380 (cancelled proposal)
* 
Arkansas Highway 380
* 
Georgia State Route 380
* 
Louisiana Highway 380
* 
Maryland Route 380
* 
New York State Route 380 (former)
* 
Ohio State Route 380
* 
Oregon Route 380
* 
Pennsylvania Route 380
* 
Puerto Rico Highway 380
* 
Tennessee State Route 380
{{Road index, 380
Canada
* New Brunswick Route 380 * Newfoundland and Labrador Route 380Japan
* Japan National Route 380
National Route 380 is a national highway of Japan connecting Yawatahama, Ehime and Kumakōgen, Ehime
Gōraiko Falls
270px, Taihō-ji
is a town in Kamiukena District, Ehime Prefecture, Japan. , the town had an estimated population of 6,92 ...
United States
* Interstate 380
* U.S. Route 380
* Arizona State Route 380 (cancelled proposal)
* Arkansas Highway 380
* Georgia State Route 380
* Louisiana Highway 380
* Maryland Route 380
* New York State Route 380 (former)
* Ohio State Route 380
* Oregon Route 380
* Pennsylvania Route 380
* Puerto Rico Highway 380
* Tennessee State Route 380
{{Road index, 380