Hexobendine is a
vasodilator
Vasodilation is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles. The process is the opposite of vasoconstriction, ...
that acts as an
adenosine reuptake inhibitor
An adenosine reuptake inhibitor (AdoRI) is a type of drug which acts as a reuptake inhibitor for the purine nucleoside and neurotransmitter adenosine by blocking the action of one or more of the equilibrative nucleoside transporters (ENTs). This i ...
.
Synthesis
![Hexobendine synthesis](https://upload.wikimedia.org/wikipedia/commons/f/f1/Hexobendine_synthesis.svg)
The reaction between 3,4,5-trimethoxybenzoyl chloride
521-61-3(1) and 3-chloropropanol
27-30-5(2) gives the corresponding ester, i.e. 3-chloropropyl 3,4,5-trimethoxybenzoate
CID:12350731 029-24-9(3). The last step involves the reaction between two molar equivalents of 3 with one molar equivalent of N,N’-dimethylethanediamine
10-70-3(4) completing the synthesis of hexobendine (5).
See also
*
Dilazep
Dilazep is a vasodilator that acts as an adenosine reuptake inhibitor.
It is used for the treatment of cardiopathy and renal disorders. Synthesis
The reaction of bis-(3-hydroxypropyl)-ethylene diamine (1) with 1-Bromo-3-chloropropane (2) give ...
References
Vasodilators
Phenol ethers
Benzoate esters
Amines
Adenosine reuptake inhibitors
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