Hepatokines (Greek ''heapto-'', liver; and ''-kinos'', movement) are proteins produced by liver cells ( hepatocytes) that are secreted into the

circulation Circulation may refer to: Science and technology * Atmospheric circulation, the large-scale movement of air * Circulation (physics), the path integral of the fluid velocity around a closed curve in a fluid flow field * Circulatory system, a bio ...

and function as hormones across the organism. Research is mostly focused on hepatokines that play a role in the regulation of metabolic diseases such as diabetes and fatty liver and include: Adropin,

ANGPTL4 Angiopoietin-like 4 is a protein that in human is encoded by the ''ANGPTL4'' gene. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2, HFARP, PGAR, or FIAF but ...

Fetuin-A alpha-2-HS-glycoprotein (AHSG, Alpha-2-Heremans-Schmid Glycoprotein) also known as fetuin-A is a protein that in humans is encoded by the ''AHSG'' gene. Fetuin-A belongs to the fetuin class of plasma binding proteins and is more abundant in feta ...

, Fetuin-B, FGF-21, Hepassocin, LECT2,

RBP4 Retinol binding protein 4, also known as RBP4, is a transporter protein for retinol (vitamin A alcohol). RBP4 has a molecular weight of approximately 21 kDa and is encoded by the ''RBP4'' gene in humans. It is mainly, though not exclusively, synt ...

, Selenoprotein P, Sex hormone-binding globulin.

References

Endocrinology Liver Peptide hormones {{Protein-stub

See also

References