Hepatitis C virus stem-loop VII is a
regulatory element
A regulatory sequence is a segment of a nucleic acid molecule which is capable of increasing or decreasing the expression of specific genes within an organism. Regulation of gene expression is an essential feature of all living organisms and v ...
found in the coding region of the
RNA-dependent RNA polymerase
RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand complementary to a given RNA template. This is in contrast to t ...
gene,
NS5B
Nonstructural protein 5B (NS5B) is a viral protein found in the hepatitis C virus (HCV). It is an RNA-dependent RNA polymerase, having the key function of replicating HCV's viral RNA by using the viral positive RNA strand as a template to catalyze ...
. Similarly to
stem-loop IV, the
stem-loop
Stem-loop intramolecular base pairing is a pattern that can occur in single-stranded RNA. The structure is also known as a hairpin or hairpin loop. It occurs when two regions of the same strand, usually complementary in nucleotide sequence when ...
structure is important (but not essential) for colony formation, though its exact function and mechanism are unknown.
See also
*
Hepatitis C alternative reading frame stem-loop
Hepatitis C alternative reading frame stem-loop is a conserved secondary structure motif identified in the RNA genome of the Hepatitis C virus (HCV) which is proposed to have an important role in regulating Translation (biology), translation and r ...
* Hepatitis C virus (HCV) cis-acting replication element (CRE)
* Hepatitis C virus 3'X element
References
External links
*
Cis-regulatory RNA elements
Hepatitis C virus
{{molecular-cell-biology-stub