Carl Peter Henrik Dam ( da, Carl Peter Henrik Dam), (21 February 1895 – 17 April 1976) was a Danish biochemist and physiologist. He was awarded the

Nobel Prize The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...

Medicine Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care pract ...

in 1943 for joint work with Edward Doisy in discovering

vitamin K Vitamin K refers to structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ...

and its role in

human Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, culture, ...

physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...

. Dam's key experiment involved feeding a

cholesterol Cholesterol is any of a class of certain organic molecules called lipids. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell mem ...

-free diet to chickens. He initially replicated experiments reported by scientists at the

Ontario Agricultural College The Ontario Agricultural College (OAC) originated at the agricultural laboratories of the Toronto Normal School, and was officially founded in 1874 as an associate agricultural college of the University of Toronto. Since 1964, it has become affili ...

(OAC). McFarlane, Graham and Richardson, working on the chick feed program at OAC, had used

chloroform Chloroform, or trichloromethane, is an organic compound with chemical formula, formula Carbon, CHydrogen, HChlorine, Cl3 and a common organic solvent. It is a colorless, strong-smelling, dense liquid produced on a large scale as a precursor to ...

to remove all fat from chick chow. They noticed that chicks fed only fat-depleted chow developed hemorrhages and started bleeding from tag sites. Dam found that these defects could not be restored by adding purified cholesterol to the diet. It appeared that—together with the cholesterol—a second compound had been extracted from the food, and this compound was called the coagulation vitamin. The new vitamin received the letter K because the initial discoveries were reported in a German journal, in which it was designated as ''Koagulationsvitamin''. He received an undergraduate degree in chemistry from the ''Copenhagen Polytechnic Institute'' (now the

Technical University of Denmark The Technical University of Denmark ( da, Danmarks Tekniske Universitet), often simply referred to as DTU, is a polytechnic university and school of engineering. It was founded in 1829 at the initiative of Hans Christian Ørsted as Denmark's fi ...

) in 1920, and was appointed as assistant instructor in chemistry at the School of Agriculture and Veterinary Medicine. By 1923 he had attained the post of instructor in biochemistry at Copenhagen University's Physiological Laboratory. He studied microchemistry at the

University of Graz The University of Graz (german: link=no, Karl-Franzens-Universität Graz, ), located in Graz, Austria, is the largest and oldest university in Styria, as well as the second-largest and second-oldest university in Austria. History The unive ...

under

Fritz Pregl Fritz Pregl ( sl, Friderik Pregl; 3 September 1869 – 13 December 1930), was a Slovenian-Austrian chemist and physician from a mixed Slovene-German-speaking background. He won the Nobel Prize in Chemistry in 1923 for making important contribut ...

in 1925, but returned to Copenhagen University, where he was appointed as an assistant professor at the Institute of Biochemistry in 1928, and assistant professor in 1929. During his time as professor at Copenhagen University he spent some time working abroad, and in 1934 submitted a thesis entitled ''Nogle Undersøgelser over Sterinernes Biologiske Betydning'' (Some investigations on the biological significance of the sterines) to Copenhagen University, and received the degree of Ph.D. in biochemistry. Between 1942 and 1945 Dam was a senior research associate at the

University of Rochester The University of Rochester (U of R, UR, or U of Rochester) is a private university, private research university in Rochester, New York. The university grants Undergraduate education, undergraduate and graduate degrees, including Doctorate, do ...

; it was during this period that he was awarded the 1943 Nobel Prize for Physiology or Medicine. In 1951, he was one of seven Nobel Laureates who attended the first Lindau Nobel Laureate Meeting.

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* including the Nobel Lecture on December 12, 1946 ''The Discovery of Vitamin K, Its Biological Functions and Therapeutical Application'' {{DEFAULTSORT:Dam, Henrik 1895 births 1976 deaths Danish biochemists Danish Nobel laureates Danish physiologists Nobel laureates in Physiology or Medicine People from Copenhagen Burials at East Bispebjerg Cemetery Vitamin researchers

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