''Helicobacter bizzozeronii'' is a species within the '' Helicobacter'' genus of Gram-negative bacteria. '' Helicobacter pylori'' is by far the best known ''Helicobacter'' species, primarily because humans infected with it may develop

gastrointestinal tract The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organ (biology), organs of the digestive syste ...

diseases such as stomach inflammation,

stomach ulcers Peptic ulcer disease (PUD) is a break in the inner lining of the stomach, the first part of the small intestine, or sometimes the lower esophagus. An ulcer in the stomach is called a gastric ulcer, while one in the first part of the intestines ...

, duodenal ulcers,

stomach cancer Stomach cancer, also known as gastric cancer, is a cancer that develops from the lining of the stomach. Most cases of stomach cancers are gastric carcinomas, which can be divided into a number of subtypes, including gastric adenocarcinomas. Lymph ...

s of the nonlymphoma type, and various subtypes of extranodal marginal zone lymphomass, e.g. those of the stomach, small intestines, large intestines, and rectumn. ''H. pylori'' is also associated with the development of

bile duct cancer Cholangiocarcinoma, also known as bile duct cancer, is a type of cancer that forms in the bile ducts. Symptoms of cholangiocarcinoma may include abdominal pain, yellowish skin, weight loss, generalized itching, and fever. Light colored s ...

and has been associated with a wide range of other diseases although its role in the development of many of these other diseases requires further study. Humans infected with ''H. bizzozeronii'' are prone to develop some of the same gastrointestinal diseases viz., stomach inflammation, stomach ulcers, duodenal ulcers, stomach cancers that are not lymphomas, and extranodal marginal B cell lymphomas of the stomach. Other non-''H. pylori'' Helicobacter species that are known to be associated with these gastrointestinal diseases are '' Helicobacter felis, Helicobacter salomonis,

Helicobacter suis ''Helicobacter suis'' (''H. suis'') is a species within the '' Helicobacter'' genus of Gram-negative bacteria. '' Helicobacter pylori'' is by far the best known ''Helicobacter'' species, primarily because humans infected with it may develop gas ...

,'' and ''

Helicobacter heilmannii s.s ''Helicobacter heilmannii s.s.'' (''H. heilmannii s.s.'') is a species within the '' Helicobacter'' genus of Gram negative bacteria. '' Helicobacter pylori'' (''H. pylori'') is by far the best known ''Helicobacter'' species primarily because human ...

.'' Because of their disease associations, these four ''Helicobacter'' species plus ''H. bizzozeronii'' are often grouped together and termed ''

Helicobacter heilmannii sensu lato ''Helicobacter heilmannii sensu lato'' refers to a group of bacterial species within the ''Helicobacter'' genus. The ''Helicobacter'' genus consists of at least 40 species of spiral-shaped (also described as corkscrew-shaped) flagellated, Gram-n ...

''. ''Helicobacter bizzozeronii'' bacteria are detected in the stomachs of their natural hosts - cats, dogs, foxes, and lynxes, as well as in the saliva of dogs. Reports suggest that individuals, including children, are infected with this bacterium by having close contact with these animals. That is, ''H. bizzozeronii''-associated diseases appear to be zoonotic diseases, i.e.

infectious diseases An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable dise ...

that are caused by pathogen that spread from animals to humans. It is important to diagnose ''H. bizzozeronii'' and the other ''H. heilmannii sensu lato'' infections in patients with the cited upper gastrointestinal tract diseases, including in particular extranodal marginal zone lymphoma of the stomach, because some of them have been successfully treated and cured using antibiotic-based drug regimens (e.g. amoxicillin, clarithromycin, plus a proton pump inhibitor or metronidazole, clarithromycin, plus a proton pump inhibitor) directed against the instigating bacterium.

References

{{Taxonbar, from=Q21267147 Gram-negative bacteria Pathogenic bacteria Campylobacterota Infectious causes of cancer Carcinogenesis Lymphoma