Hamilton Smith may refer to:
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Hamilton Lanphere Smith (1819–1903), American scientist, photographer, and astronomer
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Hamilton Smith (cricketer) (1884–1955), Hampshire cricketer
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Hamilton O. Smith
Hamilton Othanel Smith (born August 23, 1931) is an American microbiologist and Nobel laureate.
Smith was born on August 23, 1931, and graduated from University Laboratory High School of Urbana, Illinois. He attended the University of Illinois at ...
(born 1931), American microbiologist and Nobel laureate
{{human name disambiguation, Smith, Hamilton