Haloprogesterone, sold under the brand name Prohalone, is a
progestin medication which was previously marketed by
Ayerst but is now no longer available.
Chemistry
Haloprogesterone, also known as 6α-fluoro-17α-bromoprogesterone or as 6α-fluoro-17α-bromopregn-4-ene-3,20-dione, is a
synthetic pregnane
Pregnane, also known as 17β-ethylandrostane or as 10β,13β-dimethyl-17β-ethylgonane, is a C21 steroid and, indirectly, a parent of progesterone. It is a parent hydrocarbon for two series of steroids stemming from 5α-pregnane (originally allop ...
steroid and a
halogenated
derivative
In mathematics, the derivative of a function of a real variable measures the sensitivity to change of the function value (output value) with respect to a change in its argument (input value). Derivatives are a fundamental tool of calculus. ...
of
progesterone.
It is specifically a derivative of
17α-bromoprogesterone and is similar structurally to
medrogestone
Medrogestone, sold under the brand name Colprone among others, is a progestin medication which has been used in menopausal hormone therapy and in the treatment of gynecological disorders. It is available both alone and in combination with an est ...
(6-dehydro-6,17α-dimethylprogesterone),
medroxyprogesterone acetate (6α-methyl-17α-acetoxyprogesterone), and various other progestins derived from progesterone.
Synthesis
Chemical syntheses of haloprogesterone have been published.
History
Haloprogesterone was
synthesized in 1960 and was introduced for medical use by 1961.
Society and culture
Generic names
''Haloprogesterone'' is the
generic name of the drug and its and .
Brand names
Haloprogesterone was marketed under the brand name Prohalone.
References
{{Progesterone receptor modulators
Abandoned drugs
Bromoarenes
Diketones
Fluoroarenes
Pregnanes
Progestogens