HaCaT is a spontaneously transformed

aneuploid Aneuploidy is the presence of an abnormal number of chromosomes in a cell, for example a human cell having 45 or 47 chromosomes instead of the usual 46. It does not include a difference of one or more complete sets of chromosomes. A cell with any ...

immortal Immortality is the ability to live forever, or eternal life. Immortal or Immortality may also refer to: Film * ''The Immortals'' (1995 film), an American crime film * ''Immortality'', an alternate title for the 1998 British film '' The Wisdom of ...

keratinocyte Keratinocytes are the primary type of Cell (biology), cell found in the epidermis (skin), epidermis, the outermost layer of the skin. In humans, they constitute 90% of epidermal skin cells. Basal cells in the stratum basale, basal layer (''str ...

cell Cell most often refers to: * Cell (biology), the functional basic unit of life Cell may also refer to: Locations * Monastic cell, a small room, hut, or cave in which a religious recluse lives, alternatively the small precursor of a monastery w ...

line from adult human skin, widely used in scientific research. HaCaT cells are utilized for their high capacity to differentiate and proliferate ''

in vitro ''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology an ...

''. Their use in research allows for the characterization of human

using a model that is reproducible and addresses issues such as short culture lifespan and variations between cell lines that would otherwise be encountered. These cells have allowed the characterization of several processes, such as their utilization as a model system for vitamin D₃ metabolism in the skin.

References

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External links

Cellosaurus entry for HaCaTHaCaT cells
Human cell lines