Retinol dehydrogenase 11 is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''RDH11''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
RHD11, a member of the
short-chain dehydrogenase/reductase (SDR) superfamily of
oxidoreductases, is expressed at high levels in
prostate epithelium, and its expression is regulated by
androgens.
upplied by OMIMref name="entrez" />
Clinical significance
Mutations
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, mi ...
in RDH11 are associated to
retinitis pigmentosa.
References
Further reading
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