(S)-2-hydroxypropylphosphonic acid epoxidase (, ''HPP epoxidase'', ''HppE'', ''2-hydroxypropylphosphonic acid epoxidase'', ''Fom4'', ''(S)-2-hydroxypropylphosphonate epoxidase'') is an enzyme with systematic name ''(S)-2-hydroxypropylphosphonate,NADH:oxygen epoxidase''. This enzyme catalyses the following chemical reaction : (S)-2-hydroxypropylphosphonate + NADH + H⁺ + O₂

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(1R,2S)-epoxypropylphosphonate + NAD⁺ + 2 H₂O (S)-2-hydroxypropylphosphonic acid epoxidase contains one non- heme iron centre per monomer.

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* {{Portal bar, Biology, border=no EC 1.14.19