Homeobox protein Hox-C8 is a
protein that in humans is encoded by the ''HOXC8''
gene.
Function
This gene belongs to the
homeobox
A homeobox is a DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. For instance, mutations in a homeobox may change large-scale anatomical features of the full- ...
family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.
HOXC8 was found to have activity in promoting nerve growth and its expression is dysregulated in patients with
neurofibromatosis type 1.
See also
*
Homeobox
A homeobox is a DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. For instance, mutations in a homeobox may change large-scale anatomical features of the full- ...
Interactions
HOXC8 has been shown to
interact with
Mothers against decapentaplegic homolog 6 and
Mothers against decapentaplegic homolog 1.
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
External links
*
Transcription factors
{{gene-12-stub