Heterogeneous nuclear ribonucleoprotein L-like is a
protein that in humans is encoded by the HNRNPLL
gene.
Function
HNRNPLL is a master regulator of activation-induced
alternative splicing
Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to code for multiple proteins. In this process, particular exons of a gene may be ...
in
T cells. In particular, it alters splicing of
CD45 (PTPRC; MIM 151460), a
tyrosine phosphatase
Protein tyrosine phosphatases (EC 3.1.3.48, systematic name protein-tyrosine-phosphate phosphohydrolase) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins:
: proteintyrosine phosphate + H2O = ...
essential for T-cell development and
activation.
References
Further reading
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