Holocarboxylase synthetase (biotin—(propionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)), also known as protein—biotin ligase, is a family of enzymes ({{{EnzExplorer, 6.3.4.10). This enzyme is important for the effective use of
biotin, a B vitamin found in foods such as
liver
The liver is a major organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and biochemicals necessary for digestion and growth. In humans, it ...
,
egg yolks, and
milk
Milk is a white liquid food produced by the mammary glands of mammals. It is the primary source of nutrition for young mammals (including breastfed human infants) before they are able to digest solid food. Immune factors and immune-modula ...
. In many of the body's tissues, holocarboxylase synthetase activates other specific enzymes (called biotin-dependent carboxylases) by attaching biotin to them. These carboxylases are involved in many critical cellular functions, including the production and breakdown of proteins, fats, and carbohydrates.
The catalyzed reaction:
:ATP + biotin + apo-
propionyl-CoA:carbon-dioxide ligase (ADP-forming) AMP + diphosphate +
propionyl-CoA:carbon-dioxide ligase (ADP-forming)
The 3
substrates of this enzyme are
ATP,
biotin, and
apo-[propionyl-CoA:carbon-dioxide_ligase_(ADP-forming),_whereas_its_3_
apo-[propionyl-CoA:carbon-dioxide_ligase_(ADP-forming),_whereas_its_3_product_(chemistry)">products
_
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*_Product_(project_management),_a_deliverable_or_set_of_deliverables_that_contribute_to_a_business_solution
_Mathematics
*_Produ_...
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* Product (business), an item that serves as a solution to a specific consumer problem.
* Product (project management), a deliverable or set of deliverables that contribute to a business solution
Mathematics
* Produ ...