HLA-DR52 is an
HLA-DR
HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR (Human Leukocyte Antigen – DR isotype) and peptide, generally between 9 and 30 amino acids in ...
serotype that recognizes gene products of HLA-DRB3 locus. Three allele groups can produce 35 isoforms.
DRB3, DRB4, and DRB5 are minor DR beta-encoding loci, and they have been recognized as having distinct evolution,
having diverged from DRB1 around 4 million years ago.
The DRB3 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.
Alleles
Associated diseases
DR52 serotype is positively associated with systemic sclerosis,
inflammatory myopathies,
inclusion body myositis,
DRB3*01 is positively associated with sarcoidosis,
Grave's Disease,
pulmonary sarcoidosis,
DRB3*0101:DRB1*0301 is linked to Lofgren's syndrome
DRB3*0202 is also linked to Grave's disease,
serum IgG antibodies to ''Chlamydia pneumoniae'' with essential hypertension, acute necrotizing encephalopathy
DRB3*0301 is weakly associated with anticardiolipin antibodies in SLE
DRB3*0301:DRB1*1302 may be associated with Crohn's disease
DRB1 linkage
HLA-DRB3 is linked to these HLA-DR serotypes and DRB1 allele groups:
HLA-DR3
HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoi ...
- DRB1*03
HLA-DR5 -
*
HLA-DR11 - DRB1*11
*
HLA-DR12 - DRB1*12
HLA-DR6 -
*
HLA-DR13 - DRB1*13
*
HLA-DR14 - DRB1*14
HLA-DR52 -
Sjögren syndrome
Sjögren syndrome or Sjögren's syndrome (SjS, SS) is a Chronic disease, long-term autoimmune disease that affects the body's moisture-producing (lacrimal and salivary) glands, and often seriously affects other organ systems, such as the lungs, k ...
References
{{DEFAULTSORT:Hla-Dr52
HLA-DR haplotypes