HLA-DR51 is a
HLA-DR
HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR (Human Leukocyte Antigen – DR isotype) and peptide, generally between 9 and 30 amino acids in ...
serotype that recognizes the antigens encoded by the minor DR locus
HLA-DRB5
HLA class II histocompatibility antigen, DRB5 beta chain is a protein that in humans is encoded by the ''HLA-DRB5'' gene.
Function
The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a h ...
.
DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution,
having diverged from DRB1 approximately 4 million years ago.
DRB5 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB5.
Alleles
DRB5* is subdivided into two allele groups, DRB5*01 and DRB5*02. B5*01 encodes 14 alleles and 11 isoforms. B5*02 encoded 4 alleles that can generate 4 isoforms. Only 3 of these have been surveyed by serotyping. There are numerous null genes at this locus.
DRB5*01 allele group
* 14 Alleles: 11 proteins, 2 Nulls
* DR51 Serotype: *0101, *0102
* Serotype unknown: *0103 to *0107, *0109, *0110 to *0113
* Nulls: *0108N, *0110N
DRB5*02 allele group
* 4 Alleles: 4 proteins
* DR51 Serotype: *0202,
* Serotype unknown: *0203 to *0205
Associated diseases
DR51 serotype is positively associated with The following HLA-DRB5 alleles are associated with disease:
DRB5*0101:DRB1*1501 Multiple sclerosis, leprosy
DRB1 linkage
HLA-DRB5 (DR51)is linked to the following HLA-DR serotypes and DRB1 allele groups.
HLA-DR2
HLA-DR2 (DR2) of the HLA- DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele gro ...
*
HLA-DR15
HLA-DR15 (DR15) is a HLA- DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA ...
- DRB1*15
*
HLA-DR16
HLA-DR16(DR16) is a HLA- DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 ...
- DRB1*16
References
{{DEFAULTSORT:Hla-Dr51
HLA-DR haplotypes