HLA-DR17 (DR17) is an
HLA-
DR serotype that recognizes the DRB1*0301 and *0304 gene products. DR17 is found at high frequency in Western Europe (such as Western Ireland, N. Spain, Sardinia). DR17 is part of the broader antigen group
HLA-DR3
HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoi ...
and is very similar to the group
HLA-DR18
HLA-DR18 (DR18) is a HLA- DR serotype that recognizes the DRB1*0302 and *0303 gene products. Compared to DR17 which is found at high frequency in Western Europe, DR18 is found more in SE Europe and Central Asia.
Serology
DR18 recognizes the DR ...
.
Serology
DR17 recognizes the DRB1*0301, *0304 alleles.
Disease associations
By serotype
DR17 is associated with non-chronic sarcoidosis, infantile spasm/epilepsy, rabies vaccine-induced autoimmune encephalomyelitis and cardiovascular hypertrophy in subjects with arterial hypertension People with DR17 show a tendency toward benzylpenicilloyl allergies.
By allele
DRB1*0301:
diabetes mellitus type 1
Type 1 diabetes (T1D), formerly known as juvenile diabetes, is an autoimmune disease that originates when cells that make insulin (beta cells) are destroyed by the immune system. Insulin is a hormone required for the cells to use blood sugar f ...
,
myositis, early onset Graves disease, type 1 autoimmune hepatitis, inflammatory inclusion body myositis.
In autoimmune hepatitis,
DRB1*0301 correlates with more severe and difficult to treat disease.
By haplotype
DRB1*0301:DQA1*05:DQB1*0201 is associated with
diabetes mellitus type 1
Type 1 diabetes (T1D), formerly known as juvenile diabetes, is an autoimmune disease that originates when cells that make insulin (beta cells) are destroyed by the immune system. Insulin is a hormone required for the cells to use blood sugar f ...
, ovarian cancer, non-thymomic myasthenia gravis, idiopathic inflammatory myopathies, non-cancer associated Lambert-Eaton myasthenic syndrome and sarcoidosis
By phenotype
The DRB1*0301/DRB1*1501 heterozygote is linked to primary Sjögren's syndrome
Genetic Linkage
HLA-DR17 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes
are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles.
DRB1*0301 is frequently within by the "Super-B8" or ancestral
HLA haplotype:
A
*0101 : Cw
*0701 : B
*0801 : DRB1
*0301 : DQA1
*0501 : DQB1
*0201
This haplotype is known as "Super B8", "European ancestral haplotype", or "AH8.1"
References
{{DEFAULTSORT:Hla-Dr17
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