Hepatocyte growth factor-regulated tyrosine kinase substrate is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''HGS''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Interactions
HGS has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
CLTC
Clathrin heavy chain 1 is a protein that in humans is encoded by the ''CLTC'' gene.
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles ...
*
DLG4,
*
EPS15
Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the ''EPS15'' gene.
Function
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved i ...
,
IL2RB
Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the ''IL2RB'' gene. Also known as CD122; IL15RB; P70-75.
Function
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 ...
,Merlin
Merlin ( cy, Myrddin, kw, Marzhin, br, Merzhin) is a mythical figure prominently featured in the legend of King Arthur and best known as a mage, with several other main roles. His usual depiction, based on an amalgamation of historic and le ...
,[
* ]Signal transducing adaptor molecule
Signal transducing adapter molecule 1 is a protein that in humans is encoded by the ''STAM'' gene.
Function
This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein ...
[
* ]TSG101
Tumor susceptibility gene 101, also known as TSG101, is a human gene that encodes for a cellular protein of the same name.
Function
The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzy ...
.
References
External links
PDBe-KB
provides an overview of all the structure information available in the PDB for Human Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS)
Further reading
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