WAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4
(HE4) - is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''WFDC2''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
HE4 is a
tumor marker
A tumor marker is a biomarker found in blood, urine, or body tissues that can be elevated by the presence of one or more types of cancer. There are many different tumor markers, each indicative of a particular disease process, and they are used in ...
of
ovarian cancer
Ovarian cancer is a cancerous tumor of an ovary. It may originate from the ovary itself or more commonly from communicating nearby structures such as fallopian tubes or the inner lining of the abdomen. The ovary is made up of three different c ...
, with 80%
sensitivity at a
cut-off
A cut-off, battle jacket, battle vest or kutte in heavy metal subcultures, is a type of vest or jacket which originated in the U.S. military, specifically the Army Air Corps, where pilots and other aviation personnel would collect patches or o ...
of 150 pmol/L.
Function
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers.
The encoded protein is a small secretory protein, which may be involved in sperm maturation.
References
Further reading
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Biomarkers