H2CBD (DiHydroCBD, hydrogenated CBD) are cannabinoids that were first synthesized by the Todd group in 1940 by catalytic
hydrogenation
Hydrogenation is a chemical reaction between molecular hydrogen (H2) and another compound or element, usually in the presence of a Catalysis, catalyst such as nickel, palladium or platinum. The process is commonly employed to redox, reduce or S ...
of
cannabidiol.
The term "H2CBD" can refer to two different chemical compounds that differ by the site of hydrogenation with one being more known as
8,9-dihydrocannabidiol.
H2CBD,
H4-CBD
H4CBD (Hydrogenated CBD), (Tetrahydrocannibidiol), (CyclohexylCBD) is a cannabinoid that was first synthesized by the Todd group in 1940 derived from the catalytic hydrogenation of cannabidiol.
It's important to note that H4CBD, and H2-CBD and ...
, and 8,9-dihydrocannabidiol have also been referred to as "hydrogenated CBD" which may cause confusion.
Pharmacology
In 2006, it was discovered that 8,9-dihydrocannabidiol binds very weakly to the
CB1 receptor with a binding affinity higher than 1 µM, but has potential anti-inflammatory effects independent of its cannabinoid receptor action.
See also
*
Hexahydrocannabinol
Hexahydrocannabinol (HHC) is a hydrogenated derivative of tetrahydrocannabinol. It is a naturally occurring phytocannabinoid that has rarely been identified as a trace component in ''Cannabis sativa'', but can also be produced synthetically by hy ...
(hydrogenated
THC)
*
4'-Fluorocannabidiol
4'-Fluorocannabidiol (also known as PECS-101 and 4'-F-CBD, and formerly as HUF-101 and HU-474) is a fluorinated cannabidiol derivative that has more potent anxiolytic, antidepressant, antipsychotic and anti-compulsive activity in mice compared to ...
*
7-Hydroxycannabidiol
*
Abnormal cannabidiol
Abnormal cannabidiol (Abn-CBD) is a synthetic regioisomer of cannabidiol, which unlike most other cannabinoids produces vasodilator effects, lowers blood pressure, and induces cell migration, cell proliferation and mitogen-activated protein kinase ...
*
Cannabidiol dimethyl ether
*
Delta-6-cannabidiol
Delta-6-cannabidiol (∆6-CBD) is a positional isomer of cannabidiol, found in only trace amounts in natural cannabis plants but readily synthesised from cannabidiol by base-catalysed migration of the double bond.
See also
* 4'-Fluorocannabidio ...
References
Cannabinoids
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