Guadinomines are anti-infective compounds produced by '' Streptomyces'' sp. K01-0509. Guadinomine B is the most potent known inhibitor of the

Type III secretion system The type III secretion system (T3SS or TTSS), also called the injectisome, is one of the bacterial secretion systems used by bacteria to secrete their effector proteins into the host's cells to promote virulence and colonisation. The T3SS is a ...

(TTSS) of

Gram-negative bacteria Gram-negative bacteria are bacteria that do not retain the crystal violet stain used in the Gram staining method of bacterial differentiation. They are characterized by their cell envelopes, which are composed of a thin peptidoglycan cell wall ...

. The guadinomine (gdn) biosynthetic gene cluster includes 26

open reading frames In molecular biology, open reading frames (ORFs) are defined as spans of DNA sequence between the start and stop codons. Usually, this is considered within a studied region of a prokaryotic DNA sequence, where only one of the six possible readin ...

spanning 51.2 kb. ''Streptomyces'' sp. K01-0509 produces several derivatives named guadinomines A, B, C1, C2, D, and guadinomic acid.

References

Anti-infective agents {{antiinfective-drug-stub