Gonane is a chemical compound with formula , whose molecule can be described as three molecules or entities of
cyclohexane
Cyclohexane is a cycloalkane with the molecular formula . Cyclohexane is non-polar. Cyclohexane is a colorless, flammable liquid with a distinctive detergent-like odor, reminiscent of cleaning products (in which it is sometimes used). Cyclohe ...
and one of
cyclopentane
Cyclopentane (also called C pentane) is a highly flammable alicyclic hydrocarbon with chemical formula C5H10 and CAS number 287-92-3, consisting of a ring of five carbon atoms each bonded with two hydrogen atoms above and below the plane. It occ ...
, fused in a particular way. More specifically, the molecule can be described as that of
cycloheptadecane (–CH
2–)
17 with three extra bonds connecting carbons 1 to 13, 4 to 12, and 5 to 9, replacing six hydrogen atoms. It can also be viewed as the result of fusing a cyclopentane molecule with a fully
hydrogenated
Hydrogenation is a chemical reaction between molecular hydrogen (H2) and another compound or element, usually in the presence of a catalyst such as nickel, palladium or platinum. The process is commonly employed to reduce or saturate organic ...
molecule of
phenanthrene
Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) with formula C14H10, consisting of three fused benzene rings. It is a colorless, crystal-like solid, but can also appear yellow. Phenanthrene is used to make dyes, plastics and pesticides, ...
, hence the more descriptive name perhydrocyclopenta
henanthrene.
Gonane is a
tetracyclic
Tetracyclics are cyclic chemical compounds that contain four interconnected rings of atoms, e.g. Tröger's base.
They have various pharmaceutical
A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or s ...
hydrocarbon
In organic chemistry, a hydrocarbon is an organic compound consisting entirely of hydrogen and carbon. Hydrocarbons are examples of group 14 hydrides. Hydrocarbons are generally colourless and hydrophobic, and their odors are usually weak or ...
with no double bonds. It is formally the parent compound of the
steroid
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and ...
s; its carbon skeleton is called the "steroid nucleus".
Some important gonane derivatives are the
steroid hormones, characterized by
methyl group
In organic chemistry, a methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms, having chemical formula . In formulas, the group is often abbreviated as Me. This hydrocarbon group occurs in ma ...
s at the C10 and C13 positions and a
side chain at the C17 position.
Because gonane has six
centers of chirality, it has 64 (2
6) theoretically possible
stereoisomer
In stereochemistry, stereoisomerism, or spatial isomerism, is a form of isomerism in which molecules have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in ...
s,
that differ on the position of the lone hydrogens at carbons 5, 8, 9, 10, 13 and 14 in the direction perpendicular to the mean plane of the carbons. However, only a few of these stereoisomers occur in living organisms.
The most common are
5α-gonane and
5β-gonane.
File:Gonane alpha.png, 5α-Gonane
File:Gonane beta.png, 5β-Gonane
File:AB-trans-Gonan.svg, 5α-Gonane, side-perspective view
File:AB-cis-Gonan.svg, 5β-Gonane, side-perspective view
Estrane
Estrane is a C18 steroid derivative, with a gonane core.
''Estrenes'' are estrane derivatives that contain a double bond, with an example being nandrolone. ''Estratrienes'' (estrins) are estrane derivatives that contain three double bonds, for i ...
(C18) is the 13β-methyl variant of gonane,
androstane (C19) is the 10β,13β-dimethyl variant of gonane, and
pregnane (C21) is the 10β,13β-dimethyl, 17β-
ethyl variant of gonane.
The term gonane is also used to refer to a group of
progestin
A progestogen, also referred to as a progestagen, gestagen, or gestogen, is a type of medication which produces effects similar to those of the natural female sex hormone progesterone in the body. A progestin is a ''synthetic'' progestogen. Pro ...
s that are carbon 18-homologated 19-nortestosterone derivatives including
levonorgestrel
Levonorgestrel is a hormonal medication which is used in a number of birth control methods. It is combined with an estrogen to make combination birth control pills. As an emergency birth control, sold under the brand name Plan B One-Step amon ...
and its
analogues.
The term is used to distinguish them from the
estrane
Estrane is a C18 steroid derivative, with a gonane core.
''Estrenes'' are estrane derivatives that contain a double bond, with an example being nandrolone. ''Estratrienes'' (estrins) are estrane derivatives that contain three double bonds, for i ...
s (19-nortestosterone derivatives).
References
Gonanes
Polycyclic nonaromatic hydrocarbons
Steroids
{{Steroid-stub