The enzyme glycerol-1-phosphatase (EC 3.1.3.21)
catalyzes the reaction
:glycerol 1-phosphate + H
2O
glycerol + phosphate
This enzyme belongs to the family of
hydrolase
Hydrolase is a class of enzyme that commonly perform as biochemical catalysts that use water to break a chemical bond, which typically results in dividing a larger molecule into smaller molecules. Some common examples of hydrolase enzymes are este ...
s, specifically those acting on phosphoric
monoester bonds. The
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivial ...
is glycerol-1-phosphate phosphohydrolase. Other names in common use include α-glycerophosphatase, α-glycerol phosphatase, glycerol 3-phosphatase, glycerol-3-phosphate phosphatase, and glycerol 3-phosphate phosphohydrolase. This enzyme participates in
glycerolipid metabolism
Lipids are a broad group of naturally-occurring molecules which includes fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The functions of lipids include ...
.
Among the organisms that have been shown to express this enzymatic activity are ''
A. thaliana
''Arabidopsis thaliana'', the thale cress, mouse-ear cress or arabidopsis, is a small flowering plant native to Eurasia and Africa. ''A. thaliana'' is considered a weed; it is found along the shoulders of roads and in disturbed land.
A winter ...
'' (plant) via the ''AtSgpp'' and ''AtGpp'' gene products; ''
D. salina'' (alga); ''
S. cerevisiae
''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungus microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have been o ...
'' (fungus) via the ''GPP1/RHR2/YIL053W'' and ''GPP2/HOR2/YER062C'' gene products; ''
C. albicans'' (fungus) via the ''GPP1'' gene product; ''
M. tuberculosis'' (bacteria) via the ''rv1692'' gene product; and
C57BL/6N mice and
Wistar rat
A laboratory rat or lab rat is a brown rat of the subspecies '' Rattus norvegicus domestica'' which is bred and kept for scientific research. While less commonly used for research than mice (see laboratory mouse), rats have served as an impor ...
s (mammals) via the ''PGP'' gene product.
References
EC 3.1.3
Enzymes of unknown structure
{{3.1-enzyme-stub