enzymology Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

, a glucosylceramidase () is an

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

that catalyzes the

chemical reaction A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...

:D-glucosyl-N-acylsphingosine + H₂O

\rightleftharpoons

D-glucose + N-acylsphingosine Thus, the two substrates of this enzyme are D-glucosyl-N-acylsphingosine and H₂O, whereas its two

products Product may refer to: Business * Product (business), an item that serves as a solution to a specific consumer problem. * Product (project management), a deliverable or set of deliverables that contribute to a business solution Mathematics * Produ ...

are

D-glucose Glucose is a simple sugar with the molecular formula . Glucose is overall the most abundant monosaccharide, a subcategory of carbohydrates. Glucose is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, usin ...

and N-acylsphingosine. This enzyme belongs to the family of

hydrolase Hydrolase is a class of enzyme that commonly perform as biochemical catalysts that use water to break a chemical bond, which typically results in dividing a larger molecule into smaller molecules. Some common examples of hydrolase enzymes are este ...

s, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The

systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ...

of this enzyme class is D-glucosyl-N-acylsphingosine glucohydrolase. Other names in common use include: * psychosine hydrolase, * glucosphingosine glucosylhydrolase, * GlcCer-beta-glucosidase, * beta-D-glucocerebrosidase, * glucosylcerebrosidase, * beta-glucosylceramidase, * ceramide glucosidase, *

glucocerebrosidase β-Glucocerebrosidase (also called acid β-glucosidase, D-glucosyl-N-acylsphingosine glucohydrolase, or GCase) is an enzyme with glucosylceramidase activity () that is needed to cleave, by hydrolysis, the beta-glycosidic linkage of the chemical ...

, * glucosylsphingosine beta-glucosidase, * and glucosylsphingosine beta-D-glucosidase. This enzyme participates in

sphingolipid metabolism Sphingolipids are a class of lipids containing a backbone of sphingoid bases, a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sphinx because ...

and degradation of glycan structures.

Human proteins containing this domain

GBA The (GBA) is a 32-bit handheld game console developed, manufactured and marketed by Nintendo as the successor to the Game Boy Color. It was released in Japan on March 21, 2001, in North America on June 11, 2001, in the PAL region on June 22, 2 ...

belongs to

Glycoside hydrolase family 30 In molecular biology, glycoside hydrolase family 30 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a ...

GBA2 ''GBA2'' is the gene that encodes the enzyme non-lysosomal glucosylceramidase in humans. It has glucosylceramidase () activity. Function This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides ...

belongs to Glycoside hydrolase family 116.

Human proteins containing this domain

References

Further reading