A gastric chief cell (or peptic cell, or gastric zymogenic cell) is a type of gastric gland
cell that releases pepsinogen
and gastric lipase
and is the cell responsible for secretion of chymosin
in ruminants. The cell stains basophilic upon H&E stain
ing due to the large proportion of rough endoplasmic reticulum
in its cytoplasm
. Gastric chief cells are generally located deep in the mucosal layer of the stomach lining.
Chief cells release the zymogen
(enzyme precursor) pepsinogen when stimulated by a variety of factors including cholinergic
activity from the vagus nerve
and acidic condition in the stomach. Gastrin
may also act as secretagogue
It works in conjunction with the parietal cell
, which releases gastric acid
, converting the pepsinogen into pepsin
The terms ''chief cell'' and ''zymogenic
cell'' are often used without the word "gastric" to name this type of cell. However those terms can also be used to describe other cell types (for example, parathyroid chief cell
s). Chief cells are also known as peptic cells.
* Gastric acid
* Fundic glands
*List of human cell types derived from the germ layers
* - "Ultrastructure of the Cell: chief cells and enteroendocrine cell"
* - "Digestive System: Alimentary Canal: fundic stomach, gastric glands, base"
Category:Peptide hormone secreting cells