G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''GPSM2''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).
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Interactions
GPSM2 has been shown to
interact
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with
nuclear mitotic apparatus protein 1
Nuclear mitotic apparatus protein 1 is a protein that in humans is encoded by the ''NUMA1'' gene.
Interactions
Nuclear mitotic apparatus protein 1 has been shown to interact with PIM1, Band 4.1, GPSM2 and EPB41L1
Band 4.1-like protein 1 is a p ...
and
GNAI2
Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the ''GNAI2'' gene.
Interactions
GNAI2 has been shown to interact with:
* EYA2,
* GPSM2,
* Interleukin 8 receptor, alpha,
* MDFI,
* RGS5, ...
.
References
Further reading
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External links
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