Glycoprotein Ib (GPIb), also known as CD42,
is a component of the
GPIb-V-IX complex on
platelets. The GPIb-V-IX complex binds
von Willebrand factor, allowing
platelet adhesion and
platelet plug formation at sites of vascular injury.
It is deficient in the
Bernard–Soulier syndrome. A
gain-of-function mutation
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, ...
causes platelet-type
von Willebrand disease.
[McPherson & Pincus: ''Henry's Clinical Diagnosis and Management by Laboratory Methods'', 21st ed., pp. 760–2 (W. B. Saunders, 2006).]
Autoantibodies against Ib/IX can be produced in
immune thrombocytopenic purpura.
Components include
GP1BA and
GP1BB.
It complexes with
Glycoprotein IX.
References
External links
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Glycoproteins
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