Gamma-aminobutyric acid receptor-associated protein is a
protein that in humans is encoded by the ''GABARAP''
gene
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.
Function
Gamma-aminobutyric acid A receptors
ABA(A) receptorsare ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.
Moreover, GABARAP has an important function in autophagosome mediated autophagy, since it is crucial for autophagosome formation and sequestration of cytosolic cargo into double-membrane vesicles, leading to subsequent degradation after fusion with lysosomes.
In addition, GABARAP can mediate selective autophagy because it binds to so-called autophagic receptors (e.g. p62, NBr1), which bind and recruit specific cargo.
Interactions
GABARAP has been shown to
interact
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with
TFRC
Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the ''TFRC'' gene. TfR1 is required for iron import from transferrin into cells by endocytosis.
Structure and func ...
,
ULK1
ULK1 is an enzyme that in humans is encoded by the ''ULK1'' gene.
Unc-51 like autophagy activating kinase (ULK1/2) are two similar isoforms of an enzyme that in humans are encoded by the ''ULK1/2'' genes. .html" ;"title="/sup>">/sup> .html" ;"t ...
and
GABRG2
Gamma-aminobutyric acid receptor subunit gamma-2 is a protein that in humans is encoded by the ''GABRG2'' gene.
Function
Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding ...
.
A bound structure for GABARAP to GABRG2 consistent with experimental observations has been computationally derived.
References
Further reading
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{{PDB Gallery, geneid=11337