Gustav Georg Embden (10 November 1874 – 25 July 1933) was a German
physiological chemist.
Background
Gustav Embden was a son of the Hamburg lawyer and politician
George Heinrich Embden. His grandmother
Charlotte Heine was a well-known
salonnière
A salon is a gathering of people held by an inspiring host. During the gathering they amuse one another and increase their knowledge through conversation. These gatherings often consciously followed Horace's definition of the aims of poetry, "e ...
and a sister of the poet
Heinrich Heine
Christian Johann Heinrich Heine (; born Harry Heine; 13 December 1797 – 17 February 1856) was a German poet, writer and literary critic. He is best known outside Germany for his early lyric poetry, which was set to music in the form of '' Lied ...
.
Education and career
Embden initially studied in
Freiburg
Freiburg im Breisgau (; abbreviated as Freiburg i. Br. or Freiburg i. B.; Low Alemannic: ''Friburg im Brisgau''), commonly referred to as Freiburg, is an independent city in Baden-Württemberg, Germany. With a population of about 230,000 (as o ...
,
Strasbourg
Strasbourg (, , ; german: Straßburg ; gsw, label=Bas Rhin Alsatian, Strossburi , gsw, label=Haut Rhin Alsatian, Strossburig ) is the prefecture and largest city of the Grand Est region of eastern France and the official seat of the Eu ...
,
Munich
Munich ( ; german: München ; bar, Minga ) is the capital and most populous city of the States of Germany, German state of Bavaria. With a population of 1,558,395 inhabitants as of 31 July 2020, it is the List of cities in Germany by popu ...
,
Berlin
Berlin ( , ) is the capital and largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's most populous city, according to population within city limits. One of Germany's sixteen constitue ...
, and
Zurich under the famous physiologists of his time, including
Johannes von Kries
Johannes Adolf von Kries (6 October 1853 – 30 December 1928) was a German physiological psychologist who formulated the modern “duplicity” or “duplexity” theory of vision mediated by rod cells at low light levels and three types of con ...
,
Franz Hofmeister
Franz Hofmeister (30 August 1850, in Prague – 26 July 1922, in Würzburg) was an early protein scientist, and is famous for his studies of salts that influence the solubility and conformational stability of proteins. In 1902, Hofmeister became t ...
, Gaule,
Paul Ehrlich
Paul Ehrlich (; 14 March 1854 – 20 August 1915) was a Nobel Prize-winning German physician and scientist who worked in the fields of hematology, immunology, and antimicrobial chemotherapy. Among his foremost achievements were finding a cure ...
, and
Julius Richard Ewald.
In 1904, he became the director of the chemistry laboratory of the medical clinic at the Frankfurt-Sachsenhausen municipal hospital.
His research here helped to build the clinic into the Physiological Institute by 1907 and into the University Institute for Vegetative Physiology in 1914.
In the same year, he retained his directorship
and started teaching at the
University of Frankfurt am Main
Goethe University (german: link=no, Johann Wolfgang Goethe-Universität Frankfurt am Main) is a university located in Frankfurt am Main, Germany. It was founded in 1914 as a citizens' university, which means it was founded and funded by the wealt ...
.
Embden served as the
rector
Rector (Latin for the member of a vessel's crew who steers) may refer to:
Style or title
*Rector (ecclesiastical), a cleric who functions as an administrative leader in some Christian denominations
*Rector (academia), a senior official in an edu ...
of the university from 1925 to 1926.
Research
Embden conducted studies on
carbohydrate metabolism
Carbohydrate metabolism is the whole of the biochemistry, biochemical processes responsible for the metabolic anabolism, formation, catabolism, breakdown, and interconversion of carbohydrates in life, living organisms.
Carbohydrates are central t ...
and
muscle contraction
Muscle contraction is the activation of tension-generating sites within muscle cells. In physiology, muscle contraction does not necessarily mean muscle shortening because muscle tension can be produced without changes in muscle length, such as ...
, and he was the first to discover and link together all the steps involved in the conversion of
glycogen
Glycogen is a multibranched polysaccharide of glucose that serves as a form of energy storage in animals, fungi, and bacteria. The polysaccharide structure represents the main storage form of glucose in the body.
Glycogen functions as one o ...
to
lactic acid
Lactic acid is an organic acid. It has a molecular formula . It is white in the solid state and it is miscible with water. When in the dissolved state, it forms a colorless solution. Production includes both artificial synthesis as well as natu ...
.
In 1918,
Otto Fritz Meyerhof
Otto Fritz Meyerhof (; April 12, 1884 – October 6, 1951) was a German physician and biochemist who won the 1922 Nobel Prize in Physiology and Medicine.
Biography
Otto Fritz Meyerhof was born in Hannover, at Theaterplatz 16A (now:Rathenaustra ...
's work on
cellular
Cellular may refer to:
*Cellular automaton, a model in discrete mathematics
* Cell biology, the evaluation of cells work and more
* ''Cellular'' (film), a 2004 movie
*Cellular frequencies, assigned to networks operating in cellular RF bands
*Cell ...
metabolism
Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cell ...
showed that the process involved the breakdown of
glucose
Glucose is a simple sugar with the molecular formula . Glucose is overall the most abundant monosaccharide, a subcategory of carbohydrates. Glucose is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, using ...
to lactic acid. Embden is known for having worked out the precise steps involved in this breakdown. Henceforth, this cellular metabolic sequence from glycogen to lactic acid became known as the
Embden–Meyerhof pathway
Glycolysis is the metabolic pathway that converts glucose () into pyruvate (). The free energy released in this process is used to form the high-energy molecules adenosine triphosphate (ATP) and reduced nicotinamide adenine dinucleotide (NADH) ...
.
Embden had also worked on developing a technique to prevent tissue damage. In doing so, he discovered the
liver
The liver is a major Organ (anatomy), organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of proteins and biochemicals necessary for ...
's role in metabolic processes, thereby laying a foundation for understanding normal sugar metabolism and of its pathological form,
diabetes
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...
.
Some scientific historians, such as Thomas Kuhn, consider the work done in the 1930s in the laboratories of
Meyerhof,
Parnas, Embden,
Warburg
Warburg (; Westphalian language, Westphalian: ''Warberich'' or ''Warborg'') is a town in eastern North Rhine-Westphalia, central Germany on the river Diemel near the three-state point shared by Hessen, Lower Saxony and North Rhine-Westphalia. It ...
, etc. to be the mark of a true scientific revolution.
Awards
Although Embden was never awarded a
Nobel prize
The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...
, he was nominated 12 times over 8 years.
References
1874 births
1933 deaths
20th-century German chemists
People educated at the Wilhelm-Gymnasium (Hamburg)
Scientists from Hamburg
Goethe University Frankfurt faculty
Members of the Royal Society of Sciences in Uppsala
{{Germany-chemist-stub