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Guanoclor (
INN
Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway; before the advent of motorized transportation they also provided accommo ...
), also known as guanochlor, is a sympatholytic A sympatholytic (or sympathoplegic) drug is a medication that opposes the downstream effects of postganglionic nerve firing in effector organs innervated by the sympathetic nervous system (SNS). They are indicated for various functions; for example, ...
drug. It is known to bind to non-adrenergic sites in pig kidney membranes.
Synthesis
When β-(2,6-dichlorophenoxy)ethyl bromide (1) is reacted with hydrazine to give 2, and this is reacted with S-methylthiourea, guanochlor (3) results.Prepn of free base and sulfate: (1963 toPfizer
Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer ...
), C.A. 60, 14437d (1964).
References
Abandoned drugs Adrenergic release inhibitors Antihypertensive agents Chloroarenes Guanidines Phenol ethers {{Antihypertensive-stub